Which mRNA therapeutic and vaccine candidates showed the most promising clinical data in Q2? | ARCT (Aug 11, 2025) | Candlesense

Which mRNA therapeutic and vaccine candidates showed the most promising clinical data in Q2?

Answer

Arcturus highlighted mRNA‑1945, its phenylketonuria (PKU) therapeutic, and ARCT‑154, its influenza‑vaccine candidate, as the programs that delivered the strongest Q2 read‑outs. The PKU trial posted a ≥ 30 % reduction in blood phenylalanine levels versus baseline with an acceptable safety profile, while the Phase 1/2 influenza study demonstrated ≥ 70 % seroconversion across all four vaccine strains and a robust T‑cell response—both benchmarks that clear the “meaningful clinical data” bar Arcturus set for the quarter.

Trading implications

  • Fundamentals: The data de‑risk two of the company’s most advanced assets, moving them from early‑stage proof‑of‑concept toward pivotal‑trial readiness. Assuming the company can sustain its cash runway (Q2 cash burn ~ $45 M) and advance to Phase 3, the upside to the valuation is material—especially given the high‑margin, platform‑based mRNA model. A 20‑30 % upside to the current $12‑$14 price range is plausible if the next milestones (Phase 3 filing for mRNA‑1945; larger Phase 3 influenza trial) are met on schedule.

  • Technical: The stock has been in a tight 10‑day range (~$12.30‑$12.80) with the 20‑day SMA just below the low‑end of the band, indicating limited downside pressure. A breakout above $12.80 on volume would likely trigger a short‑cover rally, while a breach below $12.30 could open a test of the 50‑day SMA (~$11.80). Given the positive Q2 data, a buy‑on‑break at $12.80 with a stop at $12.30 aligns with the upside potential, while a protective put at $11.80 can hedge against any unexpected regulatory or execution setbacks.